I'm asking you to participate in an international effort to enhance our understanding of treatment of Refractory Status Epilepticus.
The aim of the study is to ascertain what treatments are being used globally in the treatment of status epilepticus in the Intensive Care setting. I am a member of the steering committee of this multinational study.
As you may know, the optimal drug treatment of refractory status epilepticus is unclear. There are controversies about the relative roles of a range of anaesthetics, antiepileptics and other physical therapies (see attached paper for details of the range of published therapies). No RCTs exist and an individual unit has too few patients to make definitive recommendations. Thus, this global audit has been devised to gather together as much information as possible, and then on this basis to discuss further research and guidelines.
The study is being academically driven with no industrial or major financial support.
We do hope you will be able to participate and thus assist in this major audit exercise which we consider is the best way forward for establishing rational treatment protocols in this difficult clinical situation.
Prof. Uri Kramer
Tel Aviv, Sourasky,MedicalCenter
- The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol
Simon Shorvon and Monica Ferlisi; Brain (2011) 134 (10): 2802-2818.doi: 10.1093/brain/awr215